Molecular Genetic Studies of Tourette Syndrome

Grant Type
Basic
Grant Year
1989
Institution Location
CT
Institution Organization Name
Yale School Of Medicine
Investigators Name
Kidd, Kenneth, PhD

We started our genetic studies of TS over a decade ago and began preparing for linkage studies with DNA markers several years ago. So far we have established cell lines on over 300 individuals in four large kindreds. Two of those are being studied in collaboration with Dr. Roger Kurlan at the University of Rochester. The initial family has now been studied for 176 polymorphic markers and the more recently collected families for somewhat fewer. The extensive exclusion data we have generated (at least 30% of the genome) have been distributed to all other TSA funded laboratories to help speed the search for a TSA gene by focusing efforts on regions not yet excluded. TSA funding during the past year has allowed us to begin collecting a fifth TS family and has allowed us to type many more markers on our existing families than would otherwise have been possible. During the coming year, we will work toward the goal of complete coverage of the genome in the initial family that has already been typed for 176 markers. In order to speed up our efforts, we will be collaborating with Dr. Lap-Chee Tsui in Toronto: we are sending DNA samples of that family to be typed in Toronto for additional markers. Kenneth K. Kidd, Ph.D., Yale School of Medicine David L. Pauls, Ph.D., Yale Child Study Center, New Haven, CT Award: $50,000 Tourette Association of America Inc. – Research Grant Award 1989