Brain Networks in Tourette Syndrome with and without Psychiatric Comorbidities

Grant Type
Grant Year
Institution Location
Institution Organization Name
New York University
Investigators Name
Feigin, Andrew, MD

This research study will evaluate the brain regions involved in the development of obsessive-compulsive disorder (OCD) and other neurobehavioral disorders in people with Tourette Syndrome (TS). Specifically, this project will compare subjects with TS manifesting solely as tics to subjects with TS and obsessive-compulsive disorder. Subjects will undergo a complete neurological and psychiatric evaluation, including detailed assessments of conditions such as OCD and Attention Deficit Hyperactivity Disorder (ADHD). A single positron emission tomography (PET) brain scan will be performed using a form of radioactively labeled sugar called fluorodeoxyglucose (FDG). This investigation may allow us to identify brain networks that are abnormal in TS, and in the behavioral disorders that sometimes occur along with TS, and also the results of this work may provide clues to the future development of improved therapies for people with TS. In addition, the information obtained from this research study could prove useful in the development of a biological marker for TS, and therefore may have implications for future genetic studies of Tourette Syndrome. Andrew Feigin, M.D. NYU/North Shore University Hospital, Manhasset, NY Award $39,200 Tourette Association of America Inc. – Research Grant Award 1999-2000