The TAA supports clinical research and clinical studies to improve the quality of life for those affected by Tourette Syndrome. The studies below are listed for informational purposes only. Visit  www.clinicaltrials.gov for a more comprehensive list of opportunities to participate in research studies in your area. To list an IRB-approved study on this page, contact Diana Shineman in the national Tourette Association office Diana.Shineman@tourette.org

Tourette Association Funded Clinical Studies

Mindfulness-Based Intervention for Adults With Tic Disorders

Online Mindfulness-Based Tic Reduction: Development and Testing

Principal Investigator: Hannah Reese, Ph.D.

Bowdoin College

 

WHO: Adults with Tourette Syndrome or Persistent (Chronic) Tic Disorder

WHAT: Pilot study of a novel 8-week online mindfulness-based intervention for tics.  The intervention consists of 1-1.5 hour weekly self-guided online mindfulness lessons, home practice (30 minutes 4-6x/week), a weekly 1-hour group videoconference, and online questionnaires.  Assessments will also be conducted before and after the intervention.

WHERE: Online with researchers from Bowdoin College and Massachusetts General Hospital

COMPENSATION: $240

CONTACT: Jin Shin: (617) 724-4354, jshin15@mgh.harvard.edu

For more information: https://research.bowdoin.edu/tic-treatment-study

Hannah E. Reese, Ph.D., Principal Investigator

Bowdoin College

(207) 798-4146

hreese@bowdoin.edu


Proof of Concept Study on the Effect of an Oral Orthotic on Tic Severity New York, NY

The Weill Cornell Medical College Department of Child and Adolescent Psychiatry is conducting a study that will test a piece of dental equipment in children and young adults with chronic tic disorders and Tourette syndrome.

Eligibility: Children and young adults ages 7-25 who make sounds or movements that they cannot control like eye blinking, facial grimaces, arm or leg twitches, throat clearing, sniffling, or other noises. If you or your child meet this criteria, you may be eligible to participate in the research study.

Study Design:

  • The study involves:
  • 5 visits
  • Medical and psychological evaluations
  • Fitting for a therapeutic dental appliance

Information/Contact: For more information please call the Weill Cornell Medical College, Department of Child and Adolescent Psychiatry at 212-746-5930

6/26/14


Neuroimaging - Tourette Association Neuroimaging Pilot Study Baltimore, MD; New York, NY; St. Louis, MO & Los Angeles, CA

In 2012, the Tourette Association re-launched its neuroimaging consortium with a grant award of $500,000. The PI’s of the new group are Bradley Schlaggar, M.D., Ph.D. and Kevin Black, M.D., both at the Washington University School of Medicine, St Louis, MO. The initial aims of the consortium are to develop a multisite working partnership; generate and reconcile pilot data from small scale fMRI studies conducted at different sites; and craft a grant application to obtain more substantial funding from the NIH to determine the neural changes that underlie TS.

If you would like to learn more about participating in this study, please contact the Study Coordinator closest to you.

 

If you would like to learn more about participating in this study, please contact the Study Coordinator closest to you.

Location: Kennedy Krieger Institute /John Hopkins University, Baltimore, MD

Principal Investigator: Stewart Mostofsky, M.D. & Harvey Singer, M.D.

Study Coordinator: Carrie Nettles: Nettles@kennedykrieger.org
(443) 923-9263

Location: New York University, NY

Principal Investigator: Adriana Di Marino, M.D.

Study Coordinator: Jessica Sunshine: sunshj01@nyumc.org

(212) 263-4723

Location: Washington Univeristy School of Medicine, St. Louis, MO

Principal Investigator: Bradley Schlaggar, M.D., Ph. D & Keving Black, M.D.

Study Coordinator: Amber Spies: spiesa@npg.wustl.edu

317-362-5041

Location: University of California, Los Angeles, CA

Principal Investigator: John Piacentini, Ph.D. & James McCracken, M.D.

Study Coordinator: Olivia Johnson: Ojohnson@mednet.ucla.edu

(310) 825-2064


Magnetic Resonance Imaging (MRI) of Brains of Children with TS Baltimore, MD

The Laboratory for Neurocognitive Imaging Research at the Kennedy Krieger Institute is currently recruiting children with Tourette Syndrome ages 9 to 12 to participate in an MRI research study to learn if there are differences between the brain’s structure and its function in children with and without Tourette Syndrome.

WHAT: The study involves one day of testing, including IQ testing, computer games, paper & pencil tasks, and a Magnetic Resonance Imaging (MRI) scan of the brain.

COMPENSATION: You will receive a copy of your child’s IQ report and $50.00

CONTACT: If you are interested please contact Carrie Nettles at 443-923-9263 or by email her at Nettles@kennedykrieger.org


Brain Differences in Children with TS Baltimore, MD

WHO: Children, ages 5-12 years, with Tourette’s

WHAT: 1-2 days (about 6 to 8 hours) of computer games, paper & pencil tasks and a Magnetic Resonance Imaging (MRI) of the brain. You will receive the results of the IQ testing and get a picture of your brain. Parents and teachers will complete a telephone screen, questionnaires, rating scales, and a structured interview.

COMPENSATION: You will receive a copy of your child’s IQ report and $50.00

WHERE: Kennedy Krieger Institute & Johns Hopkins Hospital

BENEFIT/RISK: There are no direct medical benefits or significant risks for participating in this study.

COMPENSATION: $50.00

CONTACT: Tina Kline: (410) 955-1960, tkline@jhmi.edu

E. Mark Mahone, Ph.D., Principal Investigator (NA_00028776), Kennedy Krieger Institute, Johns Hopkins School of Medicine.

Harvey Singer, MD, Co-investigator (NA_00028776), Johns Hopkins School of Medicine


Genetics - Tourette Association International Genetics Consortium Research Centers throughout the USA

There is compelling evidence to suggest that the inheritance of certain genes causes or contributes to the development of TS. The Tourette Syndrome Association’s International Consortium for Genetics (Tourette AssociationICG) has identified several chromosomes that may contain genes that predispose individuals to TS. In 2010, the Tourette AssociationICG received a grant of $1.8 million as part of the federal stimulus plan – the American Recovery and Reinvestment Act (ARRA) of 2009.  The ARRA funding will be used to confirm previous gene findings by collecting DNA from an additional 3,000 individuals with TS.
Anybody older than 6 years of age with a confirmed diagnosis of TS can participate in the study. Involvement in the study includes completing a questionnaire about tics and related problems and giving a blood sample for genetic analysis. Some people will also be asked to complete an optional interview. Interested participants can learn more about the study by visiting www.findtsgenes.org or calling 1-877-883-9950.


Non-Tourette Association Funded Studies

The studies below are listed for informational purposes only. Visit  www.clinicaltrials.gov for a more comprehensive list of opportunities to participate in research studies in your area.

To list an IRB-approved study on this page, contact Diana Shineman in the national Tourette Association office diana.shineman@tourette.org

ARTISTS Tourette Syndrome Research Study

ARTISTS 1 is conducting a Tourette Syndrome research study. In this double-blind study, doctors want to evaluate the efficacy, safety, and tolerability of TEV-50717 in children and adolescents with Tourette syndrome. TEV-50717 is a new formulation of tetrabenazine that has shown the ability to reduce dosing frequency, which could improve overall tolerability as compared to that of tetrabenazine.

Eligible patients will be randomized in a 1:1 ratio to receive either TEV-50717 or placebo. The overall treatment period will last 10 weeks, which is made up of a titration period of 2 weeks, a maintenance period of 4 weeks, and a washout period of 1 week. Total study participation will last up to 18 weeks, which includes approximately 8 visits to the study clinic.

To pre-qualify for the ARTISTS 1 study, patients must:
• Be 6 to 16 years of age, inclusive
• Weigh at least 44 pounds (20 kg) at baseline
• Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) diagnostic criteria for Tourette syndrome

All study-related visits, tests, and drugs will be provided at no cost. In addition, patients may be reimbursed for study-related travel.

For more information, please visit www.artiststudyts.com

Click here for a complete listing of contacts and sites


Biofeedback as a new treatment for Chronic Tic Disorder or Tourette Syndrome, New Haven, CT

Does your child have Chronic Tics or TS?

The Yale Magnetic Resonance Research Center is seeking research participants age 11-19 to evaluate biofeedback as a new treatment for Chronic Tic Disorder or Tourette Syndrome.

Total of 7 MRI scans, Compensation up to $600

Interested participants and family members should contact Christopher Walsh, Yale Magnetic Resonance Research Center
phone: (203)737-6055 email: christopher.walsh@yale.edu
Travel reimbursement available when one-way distance is 30 miles or greater
HIC #0206017435


CBIT Study For Children Ages 11-17 with Tics & ADHD, Massachusetts

Is your child suffering from tics and ADHD? If you have a child aged 11-17 who is bothered by tics and ADHD symptoms, we may be able to help. The Massachusetts General Hospital is conducting a no-cost clinical trial with children (ages 11 to 17 years) who are both bothered by their tics and are suffering from ADHD. Children who are eligible for the study will receive a diagnostic evaluation and either a standard or modified course of comprehensive behavioral intervention for tics at no cost. For more information, please 617-643-6204 or email jfehring@mgh.harvard.edu.


Family Accommodation in Children with Chronic Tic Disorders

Researchers at Kent State University are seeking parents of children/ adolescents ages 7-17 to complete a survey designed to help us better understand how parents of children with chronic tic disorders interact with their children. This posting has been approved by the Institutional Review Board of Kent State University.

If you have a child between the ages of 7 and 17 years and live with them 50% of the time or more, please select the following link to participate in this study.


T-Force Platinum – Nationwide Research Study for Children and Adolescents with Tourette Syndrome

A clinical research study for children and adolescents with Tourette syndrome.

Neurocrine Biosciences invites boys and girls aged 6 to 17 who have a diagnosis of Tourette syndrome to see if they may qualify for the T-Force Platinum Study. The primary purpose of this research study is to determine the safety and effectiveness of an investigational medication, that is not an antipsychotic medication, in pediatric patients with Tourette syndrome.

Each child will be evaluated to determine his or her eligibility to participate in the research study. All who qualify will receive either the investigational medication or placebo (inactive substance), study-related medical exams and study-related laboratory tests at no cost. Compensation for time and travel may also be available.

If you have friends or family who are also affected by Tourette’s, we encourage you to pass this information along. We encourage you to talk to your child’s doctor or contact the participating physician in your area.

Visit TForcePlatinum.com or ClinicalTrials.gov to learn more.


Research Study Examining Brain-Behavior interactions in Teens with Tics Providence, Rhode Island


The New Tics Study: A Novel Approach to Pathophysiology and Cause of Tic Disorders - St. Louis, MO


The University of Utah – Utah Tic Lab

University-of-Utah-Survey-Flier Tourette Association of America