Clinical Trials

The TAA supports clinical research and clinical studies to improve the quality of life for those affected by Tourette Syndrome. The studies below are listed for informational purposes only and are not being conducted by TAA, nor is any relationship being claimed between TAA and the study teams by virtue of their inclusion on this list.

Visit for a more comprehensive list of opportunities to participate in research studies in your area.

To list an IRB-approved study on this page, please submit your study via the form below. Please note that TAA can only receive requests for posting directly from the study sponsor.

Open Clinical Studies for Tourette Syndrome and Tic Disorders

The following studies are open and actively recruiting participants. Please see the description associated with each study to learn more about what is being investigated. Each study’s description also includes either an external link (which will take you away from our TAA website) or contact information, should you wish to participate in a study.

Ecopipam Phase 3 D1AMOND Study

Emalex Biosciences – Various sites

Many of our Centers of Excellence are participating sites for a research study called the Phase 3 D1AMOND study, conducted by Emalex Biosciences. This study includes children and adolescents who are at least 6 years old and adults who have Tourette Syndrome (TS). This study is evaluating a study drug called ecopipam to find out how it works over time and how safe it is in people with TS. A study drug is one that is being investigated and has not yet been approved by the United States Food and Drug Administration (FDA) or other regulatory agencies around the world for use by the general public. Tourette Syndrome affects millions of children, adolescents, and adults around the world. The currently approved therapies for this condition can sometimes have unwanted side effects. The Phase 3 D1AMOND study hopes to find out whether ecopipam is a better alternative for TS because it is designed to function differently than currently approved therapies. To learn more about this study and potential eligibility for participation, please visit this link.

Mindfulness-based Intervention for Tics (MBIT)

Johns Hopkins Medical University

In response to the critical need for new safe, efficacious, and accessible treatment options for adults with TS, our team (Drs. Reese and McGuire, and Mr. Brown) will be conducting a large, NIH-funded clinical trial to test a Mindfulness-based Intervention for Tics (MBIT) in 150 adults with TS who have moderate or greater tic severity.  In the pilot clinical trial, funded by the TAA, Dr. Reese compared group MBIT to group psychoeducation, relaxation, and supportive therapy (PRST) in adults with TS. Both interventions were delivered remotely to improve the accessibility of care. MBIT was found to be feasible, acceptable, and efficacious for reducing tic severity and impairment relative to PRST. This intervention and its remote group delivery approach offer a practical, scalable, and sustainable solution that hopes to improve therapeutic outcomes for adults with TS. Individuals with TS interested in participating and/or therapists interested in referring patients with TS to the study should contact our study team for further details or go on the website to learn more about eligibility for participation.

Additional Studies

Submit a Clinical Trial for Inclusion

Is your team conducting a study or trial that focuses on Tourette Syndrome or Tic Disorders and would like us to list it here? Thank you for your work! Please submit the form below or send study information (including a copy of an institutionally reviewed and approved research proposal, any relevant informed consent forms, and approved advertisements/flyers) to [email protected]. Our team will review and then get in touch with any questions before listing your opportunity.