The TAA supports clinical research and clinical studies to improve the quality of life for those affected by Tourette Syndrome. The studies below are listed for informational purposes only. Visit www.clinicaltrials.gov for a more comprehensive list of opportunities to participate in research studies in your area.
To list an IRB-approved study on this page, please your submit your study below.
Please note that TAA can only receive requests for posting directly from the study sponsor.
Open Clinical Studies for Tourette Syndrome and Tic Disorders
Neuroimaging - Tourette Association Neuroimaging Pilot Study Baltimore, MD; New York, NY; St. Louis, MO & Los Angeles, CA*
In 2012, the Tourette Association re-launched its neuroimaging consortium with a grant award of $500,000. The PI’s of the new group are Bradley Schlaggar, M.D., Ph.D. and Kevin Black, M.D., both at the Washington University School of Medicine, St Louis, MO. The initial aims of the consortium are to develop a multisite working partnership; generate and reconcile pilot data from small scale fMRI studies conducted at different sites; and craft a grant application to obtain more substantial funding from the NIH to determine the neural changes that underlie TS.
If you would like to learn more about participating in this study, please contact the Study Coordinator closest to you.
If you would like to learn more about participating in this study, please contact the Study Coordinator closest to you.
Location: Kennedy Krieger Institute /John Hopkins University, Baltimore, MD
Principal Investigator: Stewart Mostofsky, M.D. & Harvey Singer, M.D.
Study Coordinator: Carrie Nettles: Nettles@kennedykrieger.org
Location: New York University, NY
Principal Investigator: Adriana Di Marino, M.D.
Study Coordinator: Jessica Sunshine: email@example.com
Location: Washington Univeristy School of Medicine, St. Louis, MO
Principal Investigator: Bradley Schlaggar, M.D., Ph. D & Keving Black, M.D.
Study Coordinator: Amber Spies: firstname.lastname@example.org
Location: University of California, Los Angeles, CA
Principal Investigator: John Piacentini, Ph.D. & James McCracken, M.D.
Study Coordinator: Olivia Johnson: Ojohnson@mednet.ucla.edu
Circadian Rhythms and Light Therapy in Adults with Tourette Syndrome Disorder*
Take Part In Brain Research! Attention: Parents Of Children Ages 8 To 12 Baltimore, MD*
We are recruiting children to participate in an MRI research study to learn if there are differences between the brain’s structure and its function in children with and without Tourette Syndrome (TS).
WHO: Children with TS and typically
WHAT: Two days consisting of computer games, paper &
pencil tasks, Transcranial Magnetic Stimulation
(TMS), and a Magnetic Resonance Imaging (MRI)
scan of the brain. IQ testing and report and a
picture of your child’s brain!
WHERE: Kennedy Krieger Institute
BENEFIT: There are no significant risks or direct medical
benefits for participating in this study.
COMPENSATION: $50.00 per day of study participation.
You can contact Jon Phillips at 443-923-9254 or PhillipsJo@kennedykrieger.org.
Genetics - Tourette Association International Genetics Consortium Research Centers throughout the USA*
There is compelling evidence to suggest that the inheritance of certain genes causes or contributes to the development of TS. The Tourette Syndrome Association’s International Consortium for Genetics (Tourette AssociationICG) has identified several chromosomes that may contain genes that predispose individuals to TS. In 2010, the Tourette AssociationICG received a grant of $1.8 million as part of the federal stimulus plan – the American Recovery and Reinvestment Act (ARRA) of 2009. The ARRA funding will be used to confirm previous gene findings by collecting DNA from an additional 3,000 individuals with TS.
Anybody older than 6 years of age with a confirmed diagnosis of TS can participate in the study. Involvement in the study includes completing a questionnaire about tics and related problems and giving a blood sample for genetic analysis. Some people will also be asked to complete an optional interview. Interested participants can learn more about the study by visiting www.findtsgenes.org or calling 1-877-883-9950.
Proof of Concept Study on the Effect of an Oral Orthotic on Tic Severity New York, NY*
The Weill Cornell Medical College Department of Child and Adolescent Psychiatry is conducting a study that will test a piece of dental equipment in children and young adults with chronic tic disorders and Tourette syndrome.
Eligibility: Children and young adults ages 7-25 who make sounds or movements that they cannot control like eye blinking, facial grimaces, arm or leg twitches, throat clearing, sniffling, or other noises. If you or your child meet this criteria, you may be eligible to participate in the research study.
- The study involves:
- 5 visits
- Medical and psychological evaluations
- Fitting for a therapeutic dental appliance
Information/Contact: For more information please call the Weill Cornell Medical College, Department of Child and Adolescent Psychiatry at 212-746-5930
ARTISTS Tourette Syndrome Research Study
ARTISTS 1 is conducting a Tourette Syndrome research study. In this double-blind study, doctors want to evaluate the efficacy, safety, and tolerability of TEV-50717 in children and adolescents with Tourette syndrome. TEV-50717 is a new formulation of tetrabenazine that has shown the ability to reduce dosing frequency, which could improve overall tolerability as compared to that of tetrabenazine.
Eligible patients will be randomized in a 1:1 ratio to receive either TEV-50717 or placebo. The overall treatment period will last 10 weeks, which is made up of a titration period of 2 weeks, a maintenance period of 4 weeks, and a washout period of 1 week. Total study participation will last up to 18 weeks, which includes approximately 8 visits to the study clinic.
To pre-qualify for the ARTISTS 1 study, patients must:
• Be 6 to 16 years of age, inclusive
• Weigh at least 44 pounds (20 kg) at baseline
• Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) diagnostic criteria for Tourette syndrome
All study-related visits, tests, and drugs will be provided at no cost. In addition, patients may be reimbursed for study-related travel.
For more information, please visit www.artiststudyts.com
CBIT Study For Children Ages 11-17 with Tics & ADHD, Massachusetts
Is your child suffering from tics and ADHD? If you have a child aged 11-17 who is bothered by tics and ADHD symptoms, we may be able to help. The Massachusetts General Hospital is conducting a no-cost clinical trial with children (ages 11 to 17 years) who are both bothered by their tics and are suffering from ADHD. Children who are eligible for the study will receive a diagnostic evaluation and either a standard or modified course of comprehensive behavioral intervention for tics at no cost. For more information, please contact Erica Greenberg, MD at 617-643-934 email@example.com, or Eliza Davidson, BS: 617-643-4357 and firstname.lastname@example.org for more information.
Family Accommodation in Children with Chronic Tic Disorders
Researchers at Kent State University are seeking parents of children/ adolescents ages 7-17 to complete a survey designed to help us better understand how parents of children with chronic tic disorders interact with their children. This posting has been approved by the Institutional Review Board of Kent State University.
If you have a child between the ages of 7 and 17 years and live with them 50% of the time or more, please select the following link to participate in this study.
Speech and Ticking in Tourette's Study, University of Southern California
We are looking for adults living with Tourette to participate in a research study comparing the sounds of speech and vocal tics.
WHO: Anyone over 18 who has been diagnosed with Tourette’s syndrome is invited to participate.
WHAT: You will be recorded performing different speech tasks like describing a picture, reading some sentences and telling a story about yourself. You will be asked to tic freely during recordings. There will be two recording sessions, 3 hours the first day and 2 hours the second.
WHERE: A location of your choosing where you feel comfortable. Recording can take place anywhere as the researcher will travel to you. If you prefer, the researcher can make necessary location arrangements for you.
BENEFIT/RISK: There are no direct medical benefits or risks that you expose yourself to by participating.
CONTACT: Mairym Llorens | (787) 233-1791 | email@example.com
Sleep-Wake Rhythms Surveys in Children and Adults with Tourette's Disorder
Researchers at UCLA are recruiting children and adults with Tourette’s Disorder or other chronic tic disorders to participate in a survey assessing sleep-wake rhythms. We have separate surveys for adults, and children/parents.
Parent and Child Survey (Ages 10 to 17): The parent and child survey will take approximately 45 minutes to complete and will require both your and your child’s participation. It will include questions about your child’s demographics, medical/psychiatric history, tic severity and course, sleep-wake rhythms, general sleep habits, emotional functioning, and behavioral patterns. Upon completion of the survey, you will be able to enter into a drawing to receive a $50 Visa gift card. However, survey completion is not required to participate in this drawing.
Parent and Child Survey Link: https://www.ctrc.medsch.ucla.edu/redcap/surveys/?s=LP3RD7AWEE
Adult Survey (18 years and older): The adult survey will take approximately 30 minutes to complete. It will include questions about your demographics, sleep-wake rhythms, general sleep habits, tic severity and course, tic-related impairment, emotional functioning, and behavioral patterns. Upon completion of the survey, you will be able to enter into a drawing to receive a $50 Visa gift card. However, survey completion is not required to participate in this drawing.
Adult Survey Link: https://www.ctrc.medsch.ucla.edu/redcap/surveys/?s=NARMNLK8K8
TIC Genetics: Tourette International Collaborative Genetics Study - Yale School of Medicine
About the study:
Your family has been invited to be part of a study of families in which a child has Tourette Syndrome
and/or related disorders such as chronic vocal or motor tics and his/her parents do not. Although it is
well known that genetic factors play a role in causing tics, the responsible genes have not yet been
discovered. Recent dramatic advances in genetic techniques hold out the promise that we may soon be
able to identify such risk-conferring genes. The purpose of this study is to identify the genetic factors
that cause Tourette Syndrome and tics using a family-based approach. This will greatly contribute to our
understanding of Tourette Syndrome and may help develop new therapies in the future. This study
requires participation from a child and both biological parents, can be done in-person or remotely, and
participation will be compensated with a $100 Amazon gift card.
Emalex Biosciences – DIAMOND – A Pediatric Tourette Syndrome Research Study
Sponsor: EMALEX BIOSCIENCES
Clinical Sites: Throughout US
Patient Population: 6 to 17 years of age
Brief Description of Study: If your child has Tourette Syndrome, you know that physical (motor) and verbal (vocal) tics can be frustrating because they are unpredictable and disruptive. No matter how often tics happen or how intense they are, they can be difficult to diagnose and manage.
This study is researching an investigational drug called ecopipam to find out if it works in children and adolescents with Tourette Syndrome. The D1AMOND study will last up to 22 weeks (about 5.5 months). You and your child will have up to approximately 8 clinic visits and 3 phone calls as part of the study.
- Link for more information: To find out more and see if your child qualifies for this study please visit: https://diamondstudyts.com/taa
* Supported with funding through the TAA’s Research Grants Program.