Developing Functional MRI Probes for use in Pediatric TS Patients

Grant Type
Clinical
Grant Year
1999-2000
Institution Location
MA
Institution Organization Name
Massachusetts General Hospital
Investigators Name
Rauch, Scott, MD

Recently developed neuroimaging tools provide exciting and powerful means for investigating abnormal brain function in neuropsychiatric disorders. In particular, functional magnetic resonance imaging (fMRI) is a technique that can be used while subjects perform specially designed tasks, thereby allowing researchers to probe the function of specific brain systems. Because fMRI can be safely used in children, this is an especially promising approach for studying the brain abnormalities associated with Tourette Syndrome (TS). The first step in developing this line of research requires that candidate fMRI task paradigms be studied in a control group of non TS affected children. Thus, in the current proposal, we aim to establish a battery of fMRI cognitive tasks to study pediatric subjects. Our ultimate goal is to prove the usefulness of probes of brain function that can then be shared among neuroimaging research groups and used by them to investigate the pathophysiology of TS in pediatric subjects. Scott L. Rauch, M.D. Massachusetts General Hospital, Boston, MA Award $31,306 Tourette Association of America Inc. – Research Grant Award 1999-2000