Since Tourette Syndrome symptoms are treatable with drugs that prevent the effects of dopamine in the central nervous system (such as haloperidol and other dopamine receptor blockers), the etiology (causes) and/or pathophysiology (disease mechanisms) of the disorder may involve one or more overactive or “supersensitive” dopaminergic, neuronal tracts in the brain. Previous studies of Dr. Field indicate that a neuropeptide, (cyclo leucyl-glycine) or “CLG,” can prevent the development of supersensitivity to dopamine in several animal models. In this study, using three separate animal models, the hypothesis will be tested that CLG can reverse an already established supersensitivity. If the hypothesis is correct, CLG will have great potential as a new, non-toxic, orally available drug for Tourette Syndrome without the risk of Tardive Dyskinesia. Jeremy Z. Fields, Ph.D. Research Health Scientist Hines VA Hospital, Hines, IL Award: $14,850 Tourette Association of America Inc. – Research Grant Award 1986 Since Tourette Syndrome symptoms are treatable with drugs that prevent the effects of dopamine in the central nervous system (such as haloperidol and other dopamine receptor blockers), the etiology (causes) and/or pathophysiology (disease mechanisms) of the disorder may involve one or more overactive or “supersensitive” dopaminergic, neuronal tracts in the brain. Previous studies of Dr. Field indicate that a neuropeptide, (cyclo leucyl-glycine) or “CLG,” can prevent the development of supersensitivity to dopamine in several animal models. In this study, using three separate animal models, the hypothesis will be tested that CLG can reverse an already established supersensitivity. If the hypothesis is correct, CLG will have great potential as a new, non-toxic, orally available drug for Tourette Syndrome without the risk of Tardive Dyskinesia. Jeremy Z. Fields, Ph.D. Research Health Scientist Hines VA Hospital, Hines, IL Award: $14,850 Tourette Association of America Inc. – Research Grant Award 1986
Dopaminergic Neuromodulators for Tourette Syndrome
Grant Type
Clinical
Grant Year
1986
Institution Location
IL
Institution Organization Name
Hines Hospital
Investigators Name
Fields, Jeremy, MD