Expedited Therapeutic Outcomes for Habit Reversal Training for Youth with Chronic Tic Disorders

Grant Type
Grant Year
Institution Location
Institution Organization Name
University of California
Investigators Name
McGuire, Joseph Frank, PhD

Summary: Behavioral interventions, such as the Comprehensive Behavioral Intervention for Tics (CBIT) reduce the severity of tics. While many people who receive CBIT experience some benefit, only about half experience a clinically meaningful response. Recent research has identified several medications (called cognitive enhancers) that may increase the learning that occurs during treatments like CBIT to produce greater and/or accelerated improvement in symptoms. This study seeks to examine if one of these medications (called d-cycloserine, DCS) can accelerate improvements for children receiving behavior therapy. Joseph Frank McGuire, Ph.D. (anticipated July 2015); James McCracken, M.D.; John Piacentini, Ph.D. University of California, Los Angeles, CA; UCLA Semel Institute, Los Angeles, CA Award: $40,000 Tourette Association of America Inc. – Research Grant Award 2015-2016