Identification and Characterization of Genes Involved in Tourette Syndrome

Grant Type
Basic
Grant Year
2007-2008
Institution Location
Foreign
Institution Organization Name
Universite de Montreal Canada
Investigators Name
Rouleau, Guy, MD, PhD

Brain function is based on the transfer of information from neuron to neuron at contact points called synapses. Converging evidence suggests that disruption of synapses during brain development may have a role in the pathogenesis of Tourette Syndrome (TS), a complex and difficult to treat neuropsychiatric disorder. We hypothesize that mutations in synaptic genes may account for the genetic predisposition observed in a significant proportion of cases of TS. We therefore propose to screen 1,000 selected synaptic genes in 96 people with TS in order to attempt to identify genes that cause or predispose TS. This TSA funding will enable us to analyze a sub-set of 24 patients with a more severe form of the disorder. The screening will proceed according to methods already developed by our laboratory for two large-scale gene discovery projects. The outcomes of this work will have a significant impact, not only on the research of this and other neurological disorders, but also in the areas of patient management, health policies and the development of improved therapies. Guy A. Rouleau, M.D., Ph.D., Sylvain Chouinard, M.D., Yves Dion, M.D., Francois Richer, Ph.D. Universite de Montreal Centre de Recherche du CHUM, Montreal, Canada Award: $75,000 This Award is funded by The Lupin Foundation. Tourette Association of America Inc. – Research Grant Award 2007-2008