Linkage Studies in Tourette Syndrome

Grant Type
Basic
Grant Year
1989
Institution Location
UT
Institution Organization Name
University of Utah
Investigators Name
McMahon, William, MD

The goal of our study is to find the approximate location of the Tourette gene. Our method will utilize over 300 DNA markers in probing the chromosomes of large families including at least 5 members with TS. We will also access and analyze the presence of Attention Deficit Disorders and Obsessive Compulsive Disorder. We feel the support provided by this TSA grant will synergize our entry into the hunt for the TS gene by utilizing two resources unique to Utah. First, the Howard Hughes Medical Institute ranks among the world’s leaders in genetic mapping. Dr. Mark Leppert, senior research associate in the Hughes lab will direct the DNA processing and analysis. Secondly, we have located a family with four living generations affected with Tourette Syndrome. At least 300 family members, descended from one man with the disorder, live in the region. This grant will allow us to interview and sample this family and others. Our diagnostic team includes Dr. Filloux, a child and adult neurologist and Dr. McMahon, a child and adult psychiatrist. William M. McMahon, M.D. University of Utah, School of Medicine, Salt Lake City, UT Award: $25,000 Tourette Association of America Inc. – Research Grant Award 1989