Although a range of medication and psychosocial treatments for Tourette Syndrome (TS) and Chronic Tic Disorder (CTD) exists, a significant number of individuals either do not respond to the current treatments or find them unacceptable. Thus, it is essential that we continue to pursue novel treatment approaches. In this pilot study we aim to develop and test a modified form of Mindfulness-based Stress Reduction (MBSR) for the treatment of TS and CTD. MBSR is a well-established intervention that has garnered empirical support as a treatment for several medical and psychological conditions including chronic pain, fibromyalgia, anxiety, and recurrent major depression. Through direct practice in meditation, MBSR is designed to promote nonjudgmental moment-to-moment awareness of one’s bodily sensations, thoughts, and emotions. It has been shown to increase attentional control and decrease physiological arousal. We aim to combine traditional MBSR with the behavioral principles of Habit Reversal Training (HRT) to develop a new psychosocial intervention for TS and CTD (MBSR-tics). We will recruit 16 adults with TS or CTD for an 8-week trial of MBSR-tics. We will assess the feasibility and acceptability of the intervention at each visit as well as tic severity, and tic-related impairment and distress at baseline, endpoint, and one-month follow-up. If promising, we intend to use the results from this study to apply for NIH funding to conduct a larger trial. Hannah E. Reese, Ph.D., Sabine Wilhelm, Ph.D. Massachusetts General Hospital, Boston, MA Award: $38,548 Commentary: The investigators aim to develop and test a modified form of Mindfulness-Based Stress Reduction (MBSR) for the treatment of Tourette syndrome and chronic tic disorder. MBSR is a well-established intervention designed to promote moment-to-moment awareness of one’s bodily sensations, thoughts, and emotions that has been shown to increase attentional control and decrease physiological arousal. The investigators will combine traditional MBSR with the behavioral principles of Habit Reversal Training to develop a new tic treatment. They will assess participant satisfaction and improvement after 9 sessions of MBSR-tics completed over 8 weeks. If promising, the authors will use the results to apply for funding to conduct a larger study. Tourette Association of America Inc. – Research Grant Award 2011-2012