Network Architecture of the Brain in Tourette Syndrome and Its Phenotypic Subgroups

Grant Type
Grant Year
Institution Location
Institution Organization Name
Washington University School of Medicine
Investigators Name
Greene, Deanna Jacquelyn, PhD

Summary: Tourette syndrome (TS) is a complex, heterogeneous neuropsychiatric disorder for which the underlying brain mechanisms are not well understood. We aim to take a comprehensive approach, investigating the structure and function of the whole brain, to better this understanding. We will use sophisticated classification methods to identify brain network function and structure, measured with MRI, that distinguishes children with and without TS. We will also use graph theory methods to identify subgroups of TS based on whole brain MRI data. The results from this project have the potential to pinpoint new brain markers of TS and help understand its heterogeneity. Deanna Jacquelyn Greene, Ph.D.; Kevin J. Black, M.D.; Bradley L. Schlaggar, M.D., Ph.D. Washington University School of Medicine, Saint Louis, MO Award: $15,000 Tourette Association of America Inc. – Research Grant Award 2015-2016