Random Mapping of Tourette Syndrome: Inclusion/ Exclusion of the G-Group Chromosomes

Grant Type
Grant Year
Institution Location
Institution Organization Name
Washington University
Investigators Name
Devor, Eric, PhD

The search for the gene that causes Tourette Syndrome has begun to expand and to gain momentum. Already, large regions of the human genome have been surveyed. Unfortunately, this search has yet to yield a positive result. Undaunted, the consortium of laboratories engaged in the search goes on. For the current cycle of DNA mapping I have chosen to focus on the G-group chromosomes, numbers 21 and 22. Together these two chromosomes account for around three and one-half percent of the total human genome. A panel of recombinant DNA probes with which to screen each chromosome has been selected. Using new and ever more sophisticated computer techniques, the DNA screening data from my sixteen TS families will be sufficient to assess whether or not the elusive TS gene may be located on one of the two G-group chromosomes. Exclusion data from my laboratory will be combined with data from all other participating laboratories in the TSA funded collaborative group to further narrow the search for the TS gene. Eric J. Devor, Ph.D. Washington University School of Medicine, St. Louis, MO Award $25,000 Tourette Association of America Inc. – Research Grant Award 1989