Standardization of Diagnostic Methods for Tourette Syndrome Family Studies

Grant Type
Grant Year
Institution Location
Institution Organization Name
University of Rochester
Investigators Name
Kurlan, Roger, MD

Several large families affected by Tourette Syndrome (TS) have now been identified by ourselves and others. Careful examination of family members in combination with analysis of their genetic material (DNA) in blood samples should allow us to identify the genetic location of the TS gene. If successful, localization of the disease gene will aid in diagnosis, improve genetic counseling and should provide important clues regarding the cause and treatment of TS. Examination of family members has become more difficult due to the recent recognition that symptoms of TS are often mild and that some patients experience mainly behavioral problems, such as obsessive-compulsive disorder or attention deficits. Researchers at different universities studying TS families have used a variety of means to examine individuals resulting in some inconsistent findings. Since these genetic studies proceed optimally when findings from several families can be grouped together, we propose to develop standardized, consistent methods for examining subjects and assigning them to specific diagnoses which can be used in this international effort. In addition, we will test the reliability and validity of these methods between different scientists and different universities. Roger Kurlan, M.D. University of Rochester School of Medicine & Dentistry, Rochester, NY Award: $25,000 Tourette Association of America Inc. – Research Grant Award 1988