Summary: Approximately one half of patients with TS are also diagnosed with obsessive compulsive disorder (OCD). The high degree of overlap between these two psychiatric disorders suggests that they may arise from similar dysfunction in the brain, and a number of studies indicate that dysfunction within a region called the striatum may underlie both TS and OCD. Using a novel method to evaluate neural activity, I previously found abnormalities in striatal activity in a mouse model of OCD. In this study, I will investigate whether OCD-like behaviors and similar striatal circuit abnormalities are observed in a mouse model of TS. Kristen Kathleen Ade, PhD Depts. of Neurology & Neurobiology, Duke University Medical Center, Durham, NC Award: $40,000 Tourette Association of America Inc. – Research Grant Award 2015-2016